A novel target of hepatitis B virus mutations: Splicing of surface RNA
✍ Scribed by Thomas F. Baumert; Josef Köck; Hubert E. Blum
- Book ID
- 102242485
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 147 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0270-9139
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Genotype D occult hepatitis B virus (HBV) infections (OBIs) have a high frequency of amino acid substitutions in the major hydrophilic region of the small surface protein (S protein). This possibly reflects an escape mutation mechanism to evade detection by the host immune system. Mutations may also
HBsAg is the most important serological marker for acute or chronic hepatitis B. Nevertheless, there are reports of HBsAg-negative virus carriers, either with anti-HBc as the only marker for hepatitis B virus (HBV) infection or even positive for anti-HBs and anti-HBc. We report isolates from a patie