Genotype D occult hepatitis B virus (HBV) infections (OBIs) have a high frequency of amino acid substitutions in the major hydrophilic region of the small surface protein (S protein). This possibly reflects an escape mutation mechanism to evade detection by the host immune system. Mutations may also
Surface gene mutations of hepatitis B virus among high-risk patients with occult hepatitis B virus infection
β Scribed by Rasool Hamkar; Arezoo Aghakhani; Safyeh Soufian; Mohammad Banifazl; Nastaran Ghavami; Mahsa Nadri; Masoomeh Sofian; Farrokhlagha Ahmadi; Effat Razeghi; Ali Eslamifar; Amitis Ramezani
- Book ID
- 116408806
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 756 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0732-8893
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## Abstract Although occult hepatitis B virus (HBV) infection (HBVβDNA in serum in the absence of hepatitis B surface antigen [HBsAg]) is common in chronic hepatitis C, its characteristics are not well known. In this work, the presence of HBVβDNA (by polymerase chain reaction; PCR) and its distribu
## Abstract The production, secretion, and localization of surface proteins of hepatitis B virus (HBV) and the ratio of large to small surface protein S was studied in HepG2 cells transfected with the wildβtype and mutant preβS1 and preβS2/S promoters of HBV molecular clones 313.1 (GenBank accessio
## Abstract Occult hepatitis B virus (HBV) infection is characterized by the presence of HBV DNA while the HBV surface antigen (HBsAg) remains undetectable. The HBV genomes in five asymptomatic blood donors with occult HBV infection and low viremia (<10 to 1,000 HBV DNA copies/mL, genotype D) were