A novel synthetic approach to the ecdysone side chain via furan derivatives
β Scribed by Tetsuji Kametani; Masayoshi Tsubuki; Hideo Nemoto
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- French
- Weight
- 126 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
A New type of synthesis of (22R)-22,25-dihydroxycholesterol and its 22s isomer from pregnenolone by using furan derivatives is reported.
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## Abstract A cyclic secondary Ξ±βamino acid, viz. Lβproline, reacts with isatin derivatives via decarboxylative azomethine ylide formation and subsequent cycloaddition with various dipolarophiles to give cycloadducts in moderate to good yield. Theoretical studies have been performed to study the st