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A novel synthesis of β-trifluoromethyl-substituted isoserine via intramolecular rearrangement of imino ethers

✍ Scribed by Kenji Uneyama; Jian Hao; Hideki Amii

Book ID
104259262
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
211 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

The methodology for the construction of ~tfifluoromethyl-substituted isosaine is reported. The fluonnated cc-hydroxy-~imino esters which are the precursors to amino a~d derived isoserine were formed firsdy v/a a base catalyzedintramolecular remrangement of imino ethers, and the subsequent conversions of these compoands resultedin the formation of the deagnedisoserines andthe relatedfluorinated compounds.

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