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A novel synthesis of some new benzoyl-substituted heterocycles from 2-benzoyl-3-phenylpent-2-ene-1,5-dinitrile

✍ Scribed by Fathy M. Abdelrazek; Said A. Ghozlan; Farid A. Michael

Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
309 KB
Volume
44
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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2‐Benzoyl‐3‐phenylpent‐2‐ene‐1,5‐dinitrile 1 undergoes bromination with N‐bromosuccinimide (NBS) to afford the bromo derivative 2a. This bromo derivative undergoes reactions with sodium hydrogen sulfide, ethyl thioglycollate, hydroxylamine hydrochloride, hydrazines, cyanoacetamide, cyanacetohydrazide and urea derivatives to afford the thiophene 4, 4__H__‐thiopyran 6, 4__H__‐1,2‐oxazine 8, 4__H__‐pyridazines 10a,b, the pyridine 15, pyrrolo[1,2‐b]pyridazine 17 and the N‐substituted‐pyrrole derivatives 19a‐c respectively.

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