A novel synthesis of 5-aryl-3-phenylpyrazole from 2-aryl-3-benzoyl-1,1-cyclopropanedicarbonitrile and hydrazine
β Scribed by Zhongjiao Ren; Weiguo Cao; Jie Chen; Yu Wang; Weiyu Ding
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2006
- Tongue
- English
- Weight
- 427 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0022-152X
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β¦ Synopsis
A new process for synthesis of 5-aryl-3-phenylpyrazole is achieved. The regioselective ring-opening reaction of 2-aryl-3-benzoyl-1,1-cyclopropanedicarbonitrile with hydrazine plays a crucial role in the described process.
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## Dedicated to Professor Dr. Fritz Sauter on the occasion of his 75 th birthday 1-Acetyl-and 1-propionyl-2-pyrazolines 11-27 have been synthesized by the reaction of (3coumarinyl)chalcones 1-10 with hydrazine in hot acetic acid or propionic acid. While 5-aryl-3-(3coumarinyl)-1-phenyl-2-pyrazoline