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A novel synthesis of some 2-imino-4-thiazolidinone derivatives

โœ Scribed by Firouz Matloubi Moghaddam; Leila Hojabri

Publisher
Journal of Heterocyclic Chemistry
Year
2007
Tongue
English
Weight
386 KB
Volume
44
Category
Article
ISSN
0022-152X

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โœฆ Synopsis

An efficient and simple route is presented to the synthesis of some iminothiazolidinone derivatives. ฮฑ-Chloro amide derivatives undergo coupling reaction with isothiocyanate in the presence of a mild base, followed by nucleophilic substitution of chlorine by the sulfur atom of isothiocyanate.

๐Ÿ“œ SIMILAR VOLUMES

Synthesis of Long Chain Substituted 2-Im
Synthesis of Long Chain Substituted 2-Imino-4-Thiazolidinones and 2, 4-Thiazolidinediones
โœ Mukarram, M. ;Ahmad, I. ;Farooqi, Javed A. ;Ahmad, M. ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› John Wiley and Sons โš– 321 KB

The a-bromo palmitic, stearic and behenic acids on condensation with thiourea in the presence ofanhydrous sodium acetateyielded5-substituted- 2-imino-4-thiazolidinones in 80Yo.Acid hydrolysis of 5-substituted-2-imino-Cthiazolidinones afforded the 5-substituted-2,Cthiazolidinediones in 75 % yield. St