A novel synthesis of N,N',N''-trisubstituted guanidines
✍ Scribed by Gavin, David F.; Schnabel, Wilhelm J.; Kober, Ehrenfried H.; Robinson, Martin Alvin
- Book ID
- 125858628
- Publisher
- American Chemical Society
- Year
- 1967
- Tongue
- English
- Weight
- 794 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Hindered guanidines can be prepared by reaction of cyanamides with amines in hexafluoroisopropanol at 90-120°C. This sequence was used for preparing guanidinium acid 21 as a model for martinellic acid.
## Abstract The reaction of 2,3,4‐tri‐O‐acetyl‐β‐D‐xylopyranosyl isothiocyanate (**1**) and 2‐amino‐4‐arylthiazoles (**2**) gave xylosylthioureas **3**. These thiourea derivatives reacted with alkyl/aryl amine in the presence of HgCl~2~ to give a new series of N‐alkyl/aryl‐N″‐(4‐arylthiazol‐2‐yl)‐N