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A novel synthesis of maleic anhydride-1- and -2-13C and its subsequent conversion to labeled maleic hydrazide

✍ Scribed by John M. Patterson; Loren L. Braun; Nabeel F. Haidar; Jack C. Huang; Walter T. Smith Jr.

Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
191 KB
Volume
14
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Maleic anhydride‐1‐ and 2‐^13^C were synthesized respectively from the available aspartic acid‐4‐ and ‐3‐^13^C by way of the corresponding bromosuccinic acids and their anhydrides. The maleic anhydrides were converted into 1,2‐dihydro‐3,6‐pyrida‐zinedione‐3‐ and ‐4‐^13^C on treatment with aqueous hydrazine sulfate. Nitrogen‐15 labeled 1,2‐dihydro‐3,6‐pyridazinedione was obtained from the latter reaction using hydrazine‐^15^N sulfate.

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