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A novel synthesis of functionalized ketones via a nickel-catalyzed coupling reaction of zinc reagents with thiolesters

โœ Scribed by Toshiaki Shimizu; Masahiko Seki

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
62 KB
Volume
43
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

N Ph(CH 2 ) 3 COS DMF Ph(CH 2 ) 3 O n-Bu n-BuI + NiCl 2 , Zn 50 o C, 5 h 2 46% 1 DMF (CH 2 ) 2 COSEt MeO MeO O (CH 2 ) 4 -CO 2 Et (CH 2 ) 2 + I-(CH 2 ) 4 -CO 2 Et 3a 6 5a NiCl 2 , Zn 50 o C, 5 h TETRAHEDRON LETTERS

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