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A novel ketone synthesis by a palladium-catalyzed reaction of thiol esters and organozinc reagents

โœ Scribed by Hidetoshi Tokuyama; Satoshi Yokoshima; Tohru Yamashita; Tohru Fukuyama

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
241 KB
Volume
39
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A variety of ketones have been prepared by a palladium-catalyzed reaction of ethanethiol esters with organozinc reagents. Various functional groups, including esters, ketones, aromatic halides and aldehydes, tolerate the reaction conditions. The reaction can also be applied to the synthesis of t~-amino ketones using the corresponding L-Or-amino thiol esters without racemization.

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