A Novel Synthesis of 2-Aryllactic Acids via Electrocarboxylation of Methyl Aryl Ketones
β Scribed by Chan, A. S. C.; Huang, T. T.; Wagenknecht, J. H.; Miller, R. E.
- Book ID
- 127130939
- Publisher
- American Chemical Society
- Year
- 1995
- Tongue
- English
- Weight
- 300 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0022-3263
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A Convenient Synthesis of 2-Fluoro-Ξ±-methyl[1,1'-biphenyl]-4-acetic Acid via Rearrangement of Aryl Ketones. -For the synthesis of (Β±)-flurbiprofen (VIII), a potent antiinflammatory agent, 4 rearrangement methods are employed. The lead tetraacetate mediated 1,2-aryl shift of (V) is quite successful