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A novel sulfur-containing diterpenoid from Fritillaria anhuiensis

✍ Scribed by Qing-Yao Shou; Qing Tan; Zheng-Wu Shen

Book ID
104096594
Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
348 KB
Volume
50
Category
Article
ISSN
0040-4039

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✦ Synopsis

Two novel diterpenoids were isolated from the bulbs of Fritillaria anhuiensis S. C. Chen and S. E. Yin. Compound 1 was the first diterpenoid containing a sulfonyl group isolated from nature. Compound 2 was a novel kaurane-type diterpenoid. Their structures were determined by extensive spectroscopic analysis (IR, MS, NMR, and X-ray diffraction). Compound 1 significantly attenuated nitric oxide (NO) production of a macrophage cell line of Raw 264.7 cells stimulated with IFN-c.

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