Echinophyllins A and B, novel nitrogen-containing clerodane diterpenoids from Echinodorus macrophyllus

✍ Scribed by Jun'ichi Kobayashi; Mitsuhiro Sekiguchi; Hideyuki Shigemori; Ayumi Ohsaki *

• Book ID: 104210157
• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 164 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)00314-2

✦ Synopsis

Two novel nitrogen-containing clerodane diterpenoids, echinophyllins A (1) and B (2), were isolated from the leaves of the Brazilian medicinal plant Echinodorus macrophyllus ('Chapéu-de-couro'), and their structures and relative stereochemistry were elucidated by spectroscopic data. Echinophyllins A (1) and B (2) possess a unique α,β-unsaturated γ-lactam ring consisting of a clerodane diterpene and a tyramine unit or N-feruloyl putrescine unit, respectively.