The title total synthesis was achieved by a method featuring highly stereoselective intermolecular Diels-Alder reaction of the tetrahydroisobenzofuran 5 with the chiral butenolide 6 as the key step. The cycloadduct 4 was converted to the title alkaloid by way of the known sulfone 2 in 17 steps.
โฆ LIBER โฆ
A novel subtype of muscarinic receptor identified by homology screening
โ Scribed by Thomas Braun; Peter R. Schofield; Brenda D. Shivers; Dolan B. Pritchett; Peter H. Seeburg
- Book ID
- 115761037
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 603 KB
- Volume
- 149
- Category
- Article
- ISSN
- 0006-291X
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## Abstract Highโthroughput smallโmolecule screens hold great promise for identifying compounds with potential therapeutic value in the treatment of proteinโtrafficking diseases such as cystic fibrosis (CF) and nephrogenic diabetes insipidus (NDI). The approach usually involves expressing the mutan