A Novel Strategy for In Vitro Selection of Peptide-Drug Conjugates
β Scribed by Shuwei Li; Richard W Roberts
- Book ID
- 108486028
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 332 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1074-5521
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract __The use of peptide receptors as targets for tumorβselective therapies was envisaged years ago with the findings that receptors for different endogenous regulatory peptides are overexpressed in several primary and metastatic human tumors, and can be used as tumor antigens. Branched pep
We have designed a new dextran-peptide-methotrexate conjugate to achieve tumor-targeted delivery of chemotherapeutics. The dextran carrier was selected to allow passive targeting and enhanced permeation and retention (EPR). The peptide linker has also been optimized to allow drug release in the pres