## Abstract Our previous study showed a characteristic p53 mutational spectrum in lung tumors from lung cancer patients in the Western Pennsylvania region. To further understand the involvement of p53 mutations in lung tumor development, in this study we compared p53 mutational spectra and distribu
A Novel Somatic Point Mutation of theRETProto-oncogene in Tumor Tissues of Small Cell Lung Cancer Patients
β Scribed by Futami, Hitoyasu ;Egawa, Shin-ichi ;Tsukada, Toshihiko ;Maruyama, Kouji ;Bandoh, Shuji ;Noguchi, Masayuki ;Yamaguchi, Ken
- Book ID
- 108581132
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1995
- Tongue
- English
- Weight
- 464 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0910-5050
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## Abstract Aberrant promoter hypermethylation of several known or putative tumor suppressor genes occurs frequently during the etiopathogenesis of lung cancer and is a promising tool for cancer detection. In the present study, promoter hypermethylation of __p16^INK4A^__ and __CDH13__ genes was inv