𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Oncogene expression in small-cell lung cancer cell lines and a testicular germ-cell tumor: Activation of the N-myc gene and decreased RB mRNA

✍ Scribed by Kalle Saksela; Tomi P. Mäkelä; Kari Alitalo

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
894 KB
Volume
44
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

N-myc and L-myc proto-oncogenes are expressed in many developing embryonic tissues. In contrast to expression of the closely related c-myc gene, N-myc and L-myc expression is very restricted in adult tissues. We show that small amounts of the L-myc RNA can be detected in normal adult testicular tissue. A high level of N-myc expression from a single-copy N-myc gene was found in a malignant tumor of the testis, histopathologically defined as a seminoma. This tumor also showed a decrease of mRNA from the retinoblastoma gene (RB), which is ubiquitously expressed in all normal tissues. Strikingly similar results on elevated expression of the L-myc and N-myc genes and a lack of RB mRNA have been reported in small-cell lung cancer cell lines, and are confirmed in our study.

📜 SIMILAR VOLUMES

Amplification and expression of differen
Amplification and expression of different myc-family genes in a tumor specimen and 3 cell lines derived from one small-cell lung cancer patient during longitudinal follow-up
✍ Klaas Kok; Jan Osinga; Dick C. Schotanus; Henk H. Berendsen; Lou F. M. H. De Leu 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 French ⚖ 670 KB

In a small-cell lung carcinoma (SCLC) tumor specimen as well as in 3 cell lines derived from SCLC biopsies obtained from the same patient at successive times during the clinical course, either the N-myc gene or the c-myc gene appeared to be amplified and expressed. The initial tumor specimen, a lymp

Influence of docosahexaenoic acid in vit
Influence of docosahexaenoic acid in vitro on intracellular adriamycin concentration in lymphocytes and human adriamycin-sensitive and -resistant small-cell lung cancer cell lines, and on cytotoxicity in the tumor cell lines
✍ J. G. Zulstra; E. G. E. De Vries; F. A. J. Muskiet; L. A. Martini; H. Timmer-Bos 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 French ⚖ 619 KB

An increase in the therapeutic effects of cancer chemotherapeutic agents and circumvention of drug resistance in cancer cells might result from an increase in the intracellular drug level. Alteration of the lipid domain of the cell membrane can result in a higher intracellular drug level. This alter