Novel linker for the solid-phase synthes
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John A Josey; Catherine A Tarlton; Courtney E Payne
📂
Article
📅
1998
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Elsevier Science
🌐
French
⚖ 180 KB
A novel linker for the generation of alkyl-, acyl-and arylguanidines as an attachment point in solid phase synthesis has been developed. Introduction of a suitably functionalized thiourea to Wang resin via a carbamate linkage, followed by displacement of sulfur with a 1 ° or 2 ° amine affords resin