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A Novel Solid-Phase Synthesis of Highly Diverse Guanidines: Reactions of Primary Amines Attached to the T2* Linker

✍ Scribed by Dahmen, Stefan; Bräse, Stefan


Book ID
120214523
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
44 KB
Volume
2
Category
Article
ISSN
1523-7060

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📜 SIMILAR VOLUMES


Novel linker for the solid-phase synthes
✍ John A Josey; Catherine A Tarlton; Courtney E Payne 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 180 KB

A novel linker for the generation of alkyl-, acyl-and arylguanidines as an attachment point in solid phase synthesis has been developed. Introduction of a suitably functionalized thiourea to Wang resin via a carbamate linkage, followed by displacement of sulfur with a 1 ° or 2 ° amine affords resin