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A novel signaling pathway associated with Lyn, PI 3-kinase and Akt supports the proliferation of myeloma cells

✍ Scribed by Mohd S. Iqbal; Naohiro Tsuyama; Masanori Obata; Hideaki Ishikawa

Book ID
116299774
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
817 KB
Volume
392
Category
Article
ISSN
0006-291X

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## Abstract Lewis Y (LeY) is a carbohydrate tumor‐asssociated antigen. The majority of cancer cells derived from epithelial tissue express LeY type difucosylated oligosaccharide. Fucosyltransferase IV (FUT4) is an essential enzyme that catalyzes the synthesis of LeY oligosaccharide. Our previous st