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A novel, selective free-radical carbamoylation of heteroaromatic bases by Ce(iv) oxidation of formamide, catalysed by N-hydroxyphthalimide

✍ Scribed by Minisci, Francesco; Recupero, Francesco; Punta, Carlo; Gambarotti, Cristian; Antonietti, Fabrizio; Fontana, Francesca; Pedulli, Gian Franco


Book ID
111890836
Publisher
Royal Society of Chemistry
Year
2002
Tongue
English
Weight
90 KB
Volume
21
Category
Article
ISSN
1359-7345

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Polar effects in free-radical reactions.
✍ Francesco Minisci; Francesco Recupero; Andrea Cecchetto; Carlo Punta; Cristian G πŸ“‚ Article πŸ“… 2003 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 41 KB

## Abstract A new process for the homolytic acylation of protonated heteroaromatic bases is described; an N‐oxyl radical (PINO) generated from __N__‐hydroxyphthalimide by air oxygen and Co(II) abstracts a hydrogen atom from an aldehyde. The resulting nucleophilic acyl radical adds to a heteroaromat