A novel route to the 4-anilido-4-(methoxycarbonyl)piperidine class of analgetics
β Scribed by Feldman, Paul L.; Brackeen, Marcus F.
- Book ID
- 118121910
- Publisher
- American Chemical Society
- Year
- 1990
- Tongue
- English
- Weight
- 441 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
2-(l-Ethoxycarbnyl-4-oxoalkyl)-2-imidazolines add organometallic carbon nucleophiles to produce new lactones, whereas hydrogenation affords 1,4,5,6tetrahydropyridines and piperidines via a novel reductive cyclisation-cleavage pathway. We have recently reported (Scheme 1) the synthesis of 2-(4-oxoalk
## Abstract A new approach to 2βaminoβ6β(methoxycarbonyl)aminoβ4β(1,2,3,6βtetrahydroβ1βpyridyl)pyrimidine 1βoxide (**3**) is described. Methyl [1βethoxyβ2β(ethoxycarbonyl)βethylidene]carbamate (**5**) reacted with guanidine to the pyrimidinecarbamate **6**, which was successively transformed into m