An enantioselective synthesis of the carbapenem antibiotic (+)-ps-5 is described. The starting point is the chiral Sharpless epoxyalcohol 2 which is transformed stereospecifically to the eziridine 6. Regioeelective ring-ope&ng of 6 by'LiEt Cu followed by RuQ oxidation yields the @-sulfonamide cat-bo
โฆ LIBER โฆ
A novel ring-closure strategy for the carbapenems: the total synthesis of (+)-thienamycin
โ Scribed by Hanessian, Stephen; Desilets, Denis; Bennani, Youssef L.
- Book ID
- 126876296
- Publisher
- American Chemical Society
- Year
- 1990
- Tongue
- English
- Weight
- 838 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0022-3263
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