A novel ring cleavage reaction of oxazolines

✍ Scribed by Jeremy I. Levin; Steven M. Weinreb

• Book ID: 104220837
• Publisher: Elsevier Science
• Year: 1982
• Tongue: French
• Weight: 177 KB
• Volume: 23
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)87338-4

✦ Synopsis

An oxazoline can be cleanly converted to the parent carboxylic acid by treatment with NaOCl, followed by mild basic hydrolysis of the intermediate ebter product(s).

Oxazolines are now generally recognized as highly versatile synthons in organic chemistry.