A novel receptor ligand: 1-(1-cyclooctylpiperidin-4-yl)indolin-2-one
✍ Scribed by Parrish, Damon A. ;Deschamps, Jeffrey R. ;Jiang, Faming ;Zaveri, Nurulain T.
- Publisher
- International Union of Crystallography
- Year
- 2004
- Tongue
- English
- Weight
- 234 KB
- Volume
- 60
- Category
- Article
- ISSN
- 1600-5368
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✦ Synopsis
Single-crystal X-ray study T = 293 K Mean '(C±C) = 0.005 A Ê Disorder in main residue R factor = 0.048 wR factor = 0.135 Data-to-parameter ratio = 8.3 For details of how these key indicators were automatically derived from the article, see http://journals.iucr.org/e.
📜 SIMILAR VOLUMES
In the title molecule, C 13 H 9 FOS, the dihedral angle between the thiophene ring and the benzene ring is 10.8 (1) . The crystal packing is stabilized by C-HÁ Á ÁO and C-HÁ Á Á hydrogen bonds.
## Abstract In order to perform __in vivo__ imaging of the NR2B NMDA receptor system by positron emission tomography, a NR2B selective NMDA receptor antagonist has been labelled with carbon‐11 (half‐life: 20 min). __N__‐[4‐(4‐fluorobenzyl)piperidin‐1‐yl]‐__N__′‐(2‐oxo‐1,3‐dihydrobenzimidazol‐5‐yl)o