1-[1-(Decahydronaphthalen-1-yl)piperidin-4-yl]indolin-2-one: one of a novel series of nociceptin receptor ligands:
✍ Scribed by Parrish, Damon A. ;Deschamps, Jeffrey R. ;Jiang, Faming ;Zaveri, Nurulain T.
- Publisher
- International Union of Crystallography
- Year
- 2004
- Tongue
- English
- Weight
- 251 KB
- Volume
- 60
- Category
- Article
- ISSN
- 1600-5368
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📜 SIMILAR VOLUMES
Single-crystal X-ray study T = 293 K Mean '(C±C) = 0.005 A Ê Disorder in main residue R factor = 0.048 wR factor = 0.135 Data-to-parameter ratio = 8.3 For details of how these key indicators were automatically derived from the article, see http://journals.iucr.org/e.
In the title compound, C~19~H~27~N~3~OS, the central thienopyrimidine ring system is essentially planar. The cyclohexene ring adopts a half-chair conformation, while the piperidine ring is in a standard chair conformation. There is an intramolecular C—H...O hydrogen bond, which stabilizes the molecu
In the title molecule, C 13 H 9 FOS, the dihedral angle between the thiophene ring and the benzene ring is 10.8 (1) . The crystal packing is stabilized by C-HÁ Á ÁO and C-HÁ Á Á hydrogen bonds.
The crystal structure of the title compound, C 20 H 23 N 3 OS, is stabilized by intermolecular C-HÁ Á ÁO hydrogen bonds. The molecule contains a planar heterocyclic ring system, which forms a dihedral angle of 65.87 (1) with the adjacent tolyl ring. The piperidinyl ring has a distored chair conforma