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A novel pyrroline-5-carboxylic acid and acetoacetic acid adduct in hyperprolinaemia type II

โœ Scribed by Valerie Walker; Graham A Mills; John M Mellor; G.John Langley; R.Duncan Farrant


Book ID
117074898
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
266 KB
Volume
331
Category
Article
ISSN
0009-8981

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Aminolevulinic acid (ALA) stability within topical formulations intended for photodynamic therapy (PDT) is poor due to dimerisation to pyrazine-2,5-dipropionic acid (PY). Most strategies to improve stability use low pH vehicles, which can cause cutaneous irritancy. To overcome this problem, a novel