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A novel peptidic tachykinin antagonist which is potent at NK3 receptors

โœ Scribed by J.M. Stables; S. Arkinstall; I.J.M. Beresford; P. Seale; P. Ward; R.M. Hagan


Book ID
113237234
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
126 KB
Volume
24
Category
Article
ISSN
0143-4179

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The development of a novel series of non
โœ P. Boden; J.M. Eden; J. Hodgson; D.C. Horwell; M.C. Pritchard; J. Raphy; N. Suma ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 222 KB

In this paper we describe the transformation of a series of modified dipeptide NK 3 receptor selective ligands, previously developed from a hit identified from the screening of a dipeptide chemical library, into non-peptide, nanomolar affinity NK 3 receptor selective antagonists eg. PD160946 and PD1