A novel palladium-catalyzed cycloalkylation to isoxazoline 2-oxides. Application for the asymmetric synthesis of carbanucleosides.
β Scribed by Trost, Barry M.; Li, Leping; Guile, Simon D.
- Book ID
- 118154908
- Publisher
- American Chemical Society
- Year
- 1992
- Tongue
- English
- Weight
- 427 KB
- Volume
- 114
- Category
- Article
- ISSN
- 0002-7863
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Stannylquinones, prepared by heating 4-alkynyl-4-hydroxy-2-cyclobutenones with n-Bu$SnOMe, undergo oxidative dimerization to 2,2'-bisquinones in N-methylpyrrolidone in the presence of 10% C12Pd(PPh& and 20% CuI using a full equivalent of 1,4-benzoquinone as the stoichiometric oxidant.
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