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A novel p53 rescue compound induces p53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis

✍ Scribed by Weinmann, L; Wischhusen, J; Demma, M J; Naumann, U; Roth, P; DasMahapatra, B; Weller, M


Book ID
110017586
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
769 KB
Volume
15
Category
Article
ISSN
1350-9047

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## Abstract Methylxantine derivative, caffeine, is known to prevent the p53‐dependent apoptosis pathway via inhibition of ATM (ataxia telangiectasia mutated) kinase, which activates p53 by phosphorylation of the Ser‐15 residue. In contrast, it has been reported that caffeine induces p53‐mediated ap