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A novel one-pot synthesis of substituted 1,4-dihydropyridines and its application to total synthesis of the alkaloid isoalamarine from Alangium lamarckii Thw.

✍ Scribed by Uday Sankar Chowdhury


Book ID
108372374
Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
445 KB
Volume
46
Category
Article
ISSN
0040-4020

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Enantiomerically pure 1-chlorovinyl p-tolyl sulfoxides having two different substituents at the 2-position were synthesized from unsymmetrical ketones and (R)-(-)-chloromethyl p-tolyl sulfoxide in three steps. Treatment of the 1-chlorovinyl p-tolyl sulfoxides with cyanomethyllithium at -78Β°C to room