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A New One-Pot Method for the Synthesis of α-Siloxyamides from Aldehydes or Ketones and Its Application to the Synthesis of (−)-Bestatin

✍ Scribed by Nemoto, Hisao; Ma, Rujian; Suzuki, Ichiro; Shibuya, Masayuki


Book ID
120349836
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
40 KB
Volume
2
Category
Article
ISSN
1523-7060

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A two-step and high-yield method for the synthesis of α-thio aldehydes from aldehydes with one-carbon elongation is realized by using chloromethyl phenyl sulfoxide as a one-carbon homologating agent. The α-thio aldehydes are easily converted to desulfurized alcohols with Bu 3 SnH and AIBN in refluxi