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A Novel One-pot Synthesis of 3-[(3-Amino-4-methylaminobenzoyl pyridin-2-yl)amino]propionic Acid Ethyl Ester

✍ Scribed by Guo, Ya-jun; Huang, Yu; Yuan, Zhe-dong; Zhu, Xue-yan


Book ID
125807299
Publisher
Taylor and Francis Group
Year
2014
Tongue
English
Weight
198 KB
Volume
46
Category
Article
ISSN
0030-4948

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An expedient synthesis of (Β±)-2-amino-3-
✍ Robert N. Hanson; Farid A. Mohamed πŸ“‚ Article πŸ“… 1997 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 277 KB

## Abstract The excitatory, amino acid Β±2‐amino‐3‐(3‐hydroxy‐5‐methylisoxazol‐4‐yl)propionic acid hydrobromide was prepared in gram quantities in an 3.3% overall yield from methylbut 2‐ynoate. The key step was the facile preparation of methyl 3‐bromo‐5‐methylisoxazole‐4‐carboxylate.