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A novel nucleophilic substitution of the pyridine ring

โœ Scribed by P. Tomasik; A. Woszczyk

Book ID
104236003
Publisher
Elsevier Science
Year
1977
Tongue
French
Weight
112 KB
Volume
18
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

There are relatively few methods for direct nuoleophilic substitution of the pyridine ring. The a&nation of pyridine using either sodium amide or aodium in liquid ammonia' a8 well as in aminee2*3 ie widely known and applied.

๐Ÿ“œ SIMILAR VOLUMES

Nucleophilic substitution at the pyridin
Nucleophilic substitution at the pyridine ring. Kinetics of the reaction of 2-chloro-3,5-dinitropyridine with arylthiolates in methanol
โœ Ezzat A. Hamed ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 129 KB ๐Ÿ‘ 2 views

The reaction rates of 2-chloro-3,5-dinitropyridine 1 with a series of arylthiolates 2a-h in methanol have been measured at 25ยฐC. The products are the corresponding 2-thioaryl-3,5-dinitropyridine 3a-h. Good Hammett correlation with value ฯช1.19 was obtained suggesting an elimination-addition mechanism