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A novel nicotinic acetylcholine receptor antagonist radioligand for PET studies

✍ Scribed by Yu-Shin Ding; Kun-eek Kil; Kuo-Shyan Lin; Wei Ma; Yasuno Yokota; Ivy F. Carroll

Book ID
108073853
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
189 KB
Volume
16
Category
Article
ISSN
0960-894X

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## Abstract Imidacloprid is an exceptionally potent insecticide known from physiological studies to act at the nicotinic acetylcholine receptor. To prepare [^3^H]imidacloprid as a candidate radioligand, 6‐chloronicotinoyl chloride was reduced with NaB^2^H~4~ (in model studies) or NaB^3^H~4~ in abso