A novel mucoadhesive polymer prepared by template polymerization of acrylic acid in the presence of poly (ethylene glycol)

✍ Scribed by Hoo-Kyun Choi; Oh-Joong Kim; Chan-Kwon Chung; Chong-Su Cho

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 144 KB
• Volume: 73
• Category: Article
• ISSN: 0021-8995
• DOI: 10.1002/(sici)1097-4628(19990923)73:13<2749::aid-app23>3.0.co;2-9

✦ Synopsis

A new mucoadhesive polymer was prepared by template polymerization of acrylic acid in the presence of poly(ethylene glycol) (PEG). FTIR results indicated that a polymer complex was formed between poly(acrylic acid) (PAA) and PEG through hydrogen bonding. The hydrogen bonding in the PAA/PEG polymer complex was stronger than that in the PAA/PEG blend, and became stronger as the molecular weight of PEG increased. Glass transition temperatures (T g ) of PAA in the PAA/PEG polymer complexes was shifted to a lower temperature than that of PAA in the PAA/PEG blend. However, they tended to become higher as the molecular weight of PEG increased. The dissolution rate of the PAA/PEG polymer complex was much slower than the PAA/PEG blend, and was dependent on pH and molecular weight of the PEG. The mucoadhesive force of the PAA/PEG polymer complexes was stronger than for the PAA/PEG blend or a commercial product, Carbopol 971P NF.