A mucoadhesive polymer prepared by template polymerization of acrylic acid in the presence of poly(ethylene glycol) macromer

✍ Scribed by Myung-Kwan Chun; Hoo-Kyun Choi; Dong-Wan Kang; Oh-Joong Kim; Chong-Su Cho

• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 116 KB
• Volume: 83
• Category: Article
• ISSN: 0021-8995
• DOI: 10.1002/app.2319

✦ Synopsis

Abstract

A new mucoadhesive polymer complex was prepared by the template polymerization of acrylic acid with poly(ethylene glycol) macromer (PEGM) as a template polymer. Fourier transform infrared results showed that the poly(acrylic acid) (PAA)/PEGM mucoadhesive polymer complex was formed by hydrogen bonding between the carboxyl groups of PAA and the ether groups of PEGM. The glass‐transition temperature of the PAA/PEGM mucoadhesive polymer complexes was shifted to a lower temperature as the repeating unit ratio of PAA/PEGM in the complex decreased. The dissolution rate of the PAA/PEGM mucoadhesive polymer complex was much slower than that of the PAA/poly(ethylene glycol) (PEG) mucoadhesive polymer complex and was dependent on the pH and molecular weight of PEGM. The mucoadhesive force of the PAA/PEGM mucoadhesive polymer complexes was stronger than that of commercial Carbopol 971P NF and almost the same as that of the PAA/PEG mucoadhesive polymer complex. The PAA/PEGM interpolymer complex seemed to be a better mucoadhesive polymer matrix than the PAA/PEG interpolymer complex. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 83: 1904–1910, 2002