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A novel mouse model to characterize the mechanisms of endothelin-1-induced vascular injury

✍ Scribed by Paradis, Pierre; Coelho, Suellen C.; Rautureau, Yohann; Schiffrin, Ernesto L.


Book ID
122126422
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
48 KB
Volume
93
Category
Article
ISSN
0024-3205

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## Abstract ## Objective To explore increased susceptibility to fibrosis following experimental injury to alveolar epithelial cells (AECs) in a novel transgenic mouse model of scleroderma with fibroblast‐specific perturbation of transforming growth factor Ξ² (TGFΞ²) signaling (TΞ²RIIΞ”k‐fib mice). ##