Compound 5 (Cpd 5), a synthetic K vitamin analogue, or 2-(2-mercaptoethanol)-3-methyl-1,4-naphthoquinone, is a potent inhibitor of epidermal growth factor (EGF)-induced rat hepatocyte DNA synthesis and induces EGF receptor (EGFR) tyrosine phosphorylation. To understand the cellular responses to Cpd
โฆ LIBER โฆ
A Novel Mitochondrial Signaling Pathway Activated by Visible-to-near Infrared Radiation
โ Scribed by Tiina I. Karu; Ludmila V. Pyatibrat; Natalia I. Afanasyeva
- Book ID
- 111412791
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 870 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0031-8655
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The TAK1 MAPKKK mediates activation of JNK and NF-KB in the IL-1-activated signaling pathway. Here we report the identification of TAB2, a novel intermediate in the IL-1 pathway that functionally links TAK1 to TRAF6. Expression of TAB2 induces JNK and NF-kappaB activation, whereas a dominant-negativ