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A novel method for the mild and selective amidation of diesters and the amidation of monoesters

โœ Scribed by Zhenrong Guo; Eric D Dowdy; Wen-Sen Li; Richard Polniaszek; Edward Delaney

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
94 KB
Volume
42
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

The selective monoamidation of diesters and amidation of esters mediated by Lewis acids are described. The selective amidations of dimethyl pyridine-2,5-dicarboxylate (1) and dimethyl 2,3-indole-dicarboxylate (4) with primary and secondary amines mediated by MgCl 2 or MgBr 2 under mild conditions gave the corresponding ester-amides in high yield.

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