A novel method for the epimerization of α-aminoethers
✍ Scribed by Paul G. Gassman; Angelo J. Battisti; Koichi Shudo
- Publisher
- Elsevier Science
- Year
- 1972
- Tongue
- French
- Weight
- 180 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
The conventional method for the synthesis of a-fluoroketones was the action of per&oryl fluoride on ketone enamines. Though this reagent has been successful, mainly with steroidal ketones,') it has well-known and serious limitations. Thus the reagent can beueed only with very electron-rich olefins.
A practically useful method for the synthesis of a-thymidine from b-thymidine was developed by trimethylsilyl triflate-mediated C1%-epimerization. When 5%-O-diphenylacetyl-3%-O-toluoylthymidine was trimethylsilylated and successively treated with TMSOTf in acetonitrile, the resulting a-thymidine der