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A novel method for the detection of point mutation in DNA using single-base-coded CdS nanoprobes

✍ Scribed by Min Ye; Youyu Zhang; Haitao Li; Yuqin Zhang; Ping Tan; Hao Tang; Shouzhuo Yao


Book ID
108072049
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
624 KB
Volume
24
Category
Article
ISSN
0956-5663

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The single-strand conformational polymorphism (SSCP) method was used to look for mutations in the 3' half of exon 4 of the low-density lipoprotein receptor gene in patients with familial hypercholesterolaemia (FH). One set of conditions were found which allowed the detection of four of the mutations