A novel method for the construction of a benzene ring: a facile ring-closing reaction of (1E,3E,5E)-1-chloro-3-(p-tolylsulfonyl)-1,3,5-alkatrienes
β Scribed by Katsuyuki Ogura; Mineko Takeda; Jian R Xie; Motohiro Akazome; Shoji Matsumoto
- Book ID
- 104230108
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 94 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
1E,
3E,
5E
)-1-Chloro-3-(p-tolylsulfonyl)-1,3,5-alkatrienes (1) underwent facile ring-closure followed by spontaneous removal of hydrogen chloride to form a benzene ring. This reaction sequence occurred at relatively low temperature.
π SIMILAR VOLUMES
Synthesis and broad-spectrum anticancer activity of a novel heterocyclic compound 1 containing the title imidazo[4,5-e][1,3]diazepine ring system have been reported. The compound shows potent in vitro antitumor activity with low micromolar IC 50 's against prostate, lung, breast, and ovarian cancer
## Abstract Derivatives of the new ring system pyrrolo[3,4β__e__][1,2,3] triazolo[1,5β__a__]pyrimidine **6** were prepared in high yields in one step by reaction of 3βazidopyrrole **3** and substituted acetonitriles. Compound **6b** rearranged, upon heating in dimethyl sulfoxide in the presence of