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A novel MEN1 gene mutation

✍ Scribed by Marco F. Manzoni; Giulia M. Franchi; Samantha Menghi Sartorio; Elena Di Rosa; Chiara Cappelletti; Cecilia Piani; Cristina Cattaneo; Maurizio Ferrari; Emanuele Bosi; Paola Carrera


Book ID
113513275
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
79 KB
Volume
180
Category
Article
ISSN
0165-4608

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To clarify the role of the MEN1 gene in the tumorigenesis of sporadic adrenocortical tumors, we performed a molecular study on 35 adrenocortical lesions including 6 hyperplasias, 19 adenomas and 10 carcinomas. Loss of heterozygosity (LOH) of the MEN1 gene was assessed by PCR using an intragenic (D11