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A Novel Mechanism of TRAF Signaling Revealed by Structural and Functional Analyses of the TRADD–TRAF2 Interaction

✍ Scribed by Young Chul Park; Hong Ye; Constance Hsia; Deena Segal; Rebecca L. Rich; Hsiou-Chi Liou; David G. Myszka; Hao Wu


Book ID
117267808
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
496 KB
Volume
101
Category
Article
ISSN
0092-8674

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TAB2, a Novel Adaptor Protein, Mediates
✍ Giichi Takaesu; Satoshi Kishida; Atsushi Hiyama; Kyoko Yamaguchi; Hiroshi Shibuy 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 382 KB

The TAK1 MAPKKK mediates activation of JNK and NF-KB in the IL-1-activated signaling pathway. Here we report the identification of TAB2, a novel intermediate in the IL-1 pathway that functionally links TAK1 to TRAF6. Expression of TAB2 induces JNK and NF-kappaB activation, whereas a dominant-negativ