𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate

✍ Scribed by Falasca, M; Chiozzotto, D; Godage, H Y; Mazzoletti, M; Riley, A M; Previdi, S; Potter, B V L; Broggini, M; Maffucci, T


Book ID
110000228
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
711 KB
Volume
102
Category
Article
ISSN
0007-0920

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Discovery of 3-(2-aminoethyl)-5-(3-pheny
✍ Qianbin Li; Jingde Wu; Hui Zheng; Kai Liu; Tai L. Guo; Yuying Liu; Scott T. Eble πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 710 KB

A thiazolidine-2,4-dione derivative, 3-(2-aminoethyl)-5-(3-phenyl-propylidene)-thiazolidine-2,4-dione (2), was identified as a dual inhibitor of the Raf/MEK/ extracellular signal-regulated kinase (ERK) and the phosphatidylinositol 3-kinase (PI3K)/Akt signaling cascades. The discovered compound inhib

FGFR1/PI3K/AKT signaling pathway is a no
✍ Gregory J. Chen; Brian Weylie; Chen Hu; James Zhu; Reza Forough πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 279 KB πŸ‘ 1 views

## Abstract Fibroblast growth factor‐1 (FGF1), a prototypic member of the FGF family, is a potent angiogenic factor. Although FGF‐stimulated angiogenesis has been extensively studied, the molecular mechanisms regulating FGF1‐induced angiogenesis are poorly understood in vivo. Fumagillin, an antiang