A thiazolidine-2,4-dione derivative, 3-(2-aminoethyl)-5-(3-phenyl-propylidene)-thiazolidine-2,4-dione (2), was identified as a dual inhibitor of the Raf/MEK/ extracellular signal-regulated kinase (ERK) and the phosphatidylinositol 3-kinase (PI3K)/Akt signaling cascades. The discovered compound inhib
β¦ LIBER β¦
A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate
β Scribed by Falasca, M; Chiozzotto, D; Godage, H Y; Mazzoletti, M; Riley, A M; Previdi, S; Potter, B V L; Broggini, M; Maffucci, T
- Book ID
- 110000228
- Publisher
- Nature Publishing Group
- Year
- 2010
- Tongue
- English
- Weight
- 711 KB
- Volume
- 102
- Category
- Article
- ISSN
- 0007-0920
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