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A Novel Highly Effective Chiral Lithium Amide for Catalytic Enantioselective Deprotonation of meso-Epoxides

โœ Scribed by Masatoshi Asami; Takashi Suga; Kiyoshi Honda; Seiichi Inoue

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
531 KB
Volume
38
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A highlyenantioaelectivedeprotonationof meso-epoxideswas achievedby a catalyticamount of a new chiral lithiumamide, derived from (ZS,3aS,7aS)-2-(pyrrolidin-l-ylmethyl)octahydrO indole, in the presenceof excesalithiumdiisopropylamideto afford the correspondingallylic alcoholderivatives up to9470ee. 0 1997 Elsevier ScienceLtd.

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