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A novel high throughput screening assay for HCV NS3 serine protease inhibitors

โœ Scribed by Yevgeny Berdichevsky; Romy Zemel; Larisa Bachmatov; Alex Abramovich; Ruth Koren; Peramachi Sathiyamoorthy; Avi Golan-Goldhirsh; Ran Tur-Kaspa; Itai Benhar


Book ID
114139987
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
437 KB
Volume
107
Category
Article
ISSN
0166-0934

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A High-Throughput Radiometric Assay for
โœ Mauro Cerretani; Laura Di Renzo; Sergio Serafini; Alessandra Vitelli; Nadia Genn ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 127 KB

A novel radiometric in vitro assay for discovery of inhibitors of hepatitis C viral protease activity, suitable for high-throughput screening, was developed. The NS3 protein of hepatitis C virus (HCV) contains a serine protease, whose function is to process the majority of the nonstructural proteins