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A Novel Hemisynthesis of the 19-Demethyl Analogue of Calcimycin (or A23187).

✍ Scribed by Stephane Vila; Isabelle Canet; Jacques Guyot; Georges Jeminet

Book ID
101942155
Publisher
John Wiley and Sons
Year
2003
Weight
7 KB
Volume
34
Category
Article
ISSN
0931-7597

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[4-3H]-labelling of the calcium ionophor
[4-3H]-labelling of the calcium ionophore A 23187 (calcimycin)
✍ M. Prudhomme; G. Jeminet; D. Schott; J. L. Morgat; P. Beaulieu πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 French βš– 214 KB

4-3H-labelled] -A 23187 (or calcimycin) has been obtained as a magnesium salt from the corresponding 4-bromo derivative using tritiated hydrogen gas in the presence of 10% Pd/C catalyst. The specific radioactivity proved to be 50.6 Ci/mmole (1872.2 GBq/m mole).