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A novel germline mutation of MEN 1 gene in a patient with acromegaly and multiple endocrine tumors

✍ Scribed by Pinna, G.; Orgiana, G.; Carcassi, C.; Alba, F.; Cetani, F.; Pardi, E.; Marcocci, C.; Mariotti, S.


Book ID
125337342
Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
251 KB
Volume
27
Category
Article
ISSN
0391-4097

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A novel germline CDKN1B mutation causing
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Multiple endocrine neoplasia (MEN) syndromes are characterized by tumors involving two or more endocrine glands. Two MEN syndromes have long been known: MEN1 and MEN2, caused by germline mutations in __MEN1__ or __RET__, respectively. Recently, mutations in __CDKN1B__, encoding the cyclin-dependent